“Top agricultural scientists from around the world have taken up the challenge of sustainable agriculture, with the specific focus on integrating agronomic, climatological, biophysical and socio-economic perspectives and processes. Every chapter (of the Handbook) contributes to addressing the growing food-security challenges facing the world.”Climate effects on agriculture are of increasing concern in both the scientific and policy communities because of the growing population and the greater uncertainty in the weather during growing seasons. Changes in production are directly linked to variations in temperature and precipitation during the growing season and often to the offseason changes in weather because of soil water storage to replenish the soil profile. This is not an isolated problem but one of worldwide interest because each country has concerns about their food security.The Agricultural Model Intercomparison and Improvement Project (AgMIP) was developed to evaluate agricultural models and intercompare their ability to predict climate impacts. In sub-Saharan Africa and South Asia, South America and East Asia, AgMIP regional research teams (RRTs) are conducting integrated assessments to improve understanding of agricultural impacts of climate change (including biophysical and economic impacts) at national and regional scales. Other AgMIP initiatives include global gridded modeling, data and information technology (IT) tool development, simulation of crop pests and diseases, site-based crop-climate sensitivity studies, and aggregation and scaling.