The triple helix of university–industry–government interactions is a universal model for the development of the knowledge-based society, through innovation and entrepreneurship. It draws from the innovative practice of Massachusetts Institute of Technology (MIT) with industry and government in inventing a regional renewal strategy in early 20th-century New England. Parallel experiences were identified in “Silicon Valley,” where Stanford University works together with industry and government. Triple helix is identified as the secret of such innovative regions. It may also be found in statist or laissez-faire societies, globally.

The triple helix focuses on “innovation in innovation” and the dynamic to foster an innovation ecosystem, through various hybrid organizations, such as technology transfer offices, venture capital firms, incubators, accelerators, and science parks.

This second edition develops the practical and policy implications of the triple helix model with case studies exemplifying the meta-theory, including:

• how to make an innovative region through the triple helix approach;

• balancing development and sustainability by “triple helix twins";

• triple helix matrix to analyze regional innovation globally; and

• case studies on the Stanford's StartX accelerator; the Ashland, Oregon Theater Arts Clusters; and Linyi regional innovation in China.

The Triple Helix as a universal innovation model can assist students, researchers, managers, entrepreneurs, and policymakers to understand the roles of university, industry, and government in forming and developing “an innovative region,” which has self-renewal and sustainable innovative capacity.

Trina Hoefling has been at the forefront in the field of remote management training, leading with the message that “Technology is the enabler, but People are the key.” Trina is an organization development and transformational change consultant, graduate school professor and master teacher, strategic facilitator, leadership coach and virtual team collaboration expert. A noted author and speaker, she is also a contributing chapter author in The Handbook of High Performance Virtual Teams, “The Three-Fold Path: Building Trust in a Virtual Team.” Trina is an accomplished thought leader who has never lost her passion for helping people and organizations grow. She especially enjoys being an online learning engagement facilitator, coach and shadow consultant to support today’s career professionals, teams and committed organizations.